Infants with loss of function filaggrin mutations show augmented response to early life, short term skin barrier protection compared to filaggrin wild type infants; results from the STOP-AD trial.

Jonathan Hourihane,Claudio Nico,Dhanis Lad,Gerwin Puppels,Carol Ni Chaoimh,Colin Wong,John Common,Peter Caspers,Alan Irvine

doi:10.1016/j.jaci.2022.12.454

Infants with loss of function filaggrin mutations show augmented response to early life, short term skin barrier protection compared to filaggrin wild type infants; results from the STOP-AD trial.

Jonathan Hourihane, Claudio Nico + Show 7 more

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https://doi.org/10.1016/j.jaci.2022.12.454

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Journal: The Journal of Allergy and Clinical Immunology

Publication Date: Feb 1, 2023

Affiliation: University College Cork, Royal College of Surgeons in Ireland

#Risk Factor For Atopic Dermatitis #Filaggrin + Show 8 more

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Abstract

Loss-of-function (LoF) filaggrin (FLG)-mutations are the strongest genetic risk factor for atopic dermatitis (AD). The STOP-AD study showed early initiation of daily specialized emollient, used only until 2 months, reduces the incidence of AD in the first year of life in high-risk infants.

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