Infantile Central Myofibroma of the Mandible:

Abstract

Oral myofibroma is an uncommon benign tumor that has great tendency to involve oral soft tissues with bony involvementremains a rarity. Most myofibromas exhibit a benign slow clinical course however intra-osseous lesions could be mistakenwith many aggressive tumors which necessitate accurate diagnosis. The aim of this report is to shed light on a rare caseof infantile central myofibroma of the mandible. Case report: A 6-month-old girl presented with an expansible painless leftmandibular swelling. Radiographic examination revealed a well-defined, unilocular, radiolucent lesion with cortical erosions.Histopathological examination showed a highly cellular, encapsulated mass comprised of spindle-shaped and smaller roundor polygonal cells in a vague biphasic pattern. Immunohistochemically, tumor cells showed strong cytoplasmic staining forα-SMA, weak Ki-67 and negative desmin, CD34 and S-100 protein. Accordingly, conservative surgical excision with bonecurettage was performed. Postoperative follow-up revealed excellent healing with no evidence of recurrence.