Abstract
Type 1 (insulin-dependent) Diabetes Mellitus is a chronic autoimmune disorder of genetically susceptible hosts, caused by the interaction of uncertain environmental factors with the products of 20+ predisposing genes.1 Self-reactive T lymphocytes, targeting components of the pancreatic islets of Langerhans, accumulate in that locale early in life and begin a slow process, called “prediabetes”. Progressive prediabetes leads to the expansion of autoreactive T cells,2 with increasingly efficient destruction of insulin producing beta cells and their precursors.
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