Abstract

RESULTS: The NEC cohort comprised of 5,886 infants. Male gender, birth-weight, gestational age, maternal age and number of prenatal visits were associated with higher mortality (p 0.05). Neonates with PDA (23vs.14%), cyanotic/hypoperfusion heart disease (55% vs.17%), RDS (21% vs.13%), pulmonary hemorrhage/ pulmonary interstitial emphysema (36% vs.15%), IVH (20-55% vs.15%), sepsis (21% vs.13%), acidosis (35% vs.17%), or asphyxia (40% vs.18%) exhibited higher mortality (p 0.05). Neonates undergoing abdominal surgery (34% vs.10%), PDA ligation (25% vs.17%), congenital heart repair (29% vs.18%), and ECMO (60% vs.18%) also had a higher rate of NEC and mortality (p 0.05). Higher acuity NICUs (level III) compared to lower acuity (level II) demonstrated a higher mortality rate (23% vs.10%, p 0.05). Stepwise logistic regression suggested lower birth-weight, lower maternal age, IVH, acidosis, cyanotic/hypoperfusion heart disease, abdominal NEC surgery and ECMO (p 0.05) were independent risk factors for mortality.

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