INFγ, TNFα, IL-6 LEVELS IN THE PERIPHERAL BLOOD SERUM IN DIFFERENT CLINICAL COURSES OF NONSPECIFIC VULVOVAGINITIS IN ADOLESCENT GIRLS

Smailova Lazat Kenzhebekovna,Bilalova Gulshat Tursunovna,Kurmanova Almagul Medeubaeva

doi:10.29121/granthaalayah.v5.i7.2017.2147

Abstract

The conducted study showed that increased production of anti-inflammatory INFγ cytokine is observed in girls and adolescents with acute nonspecific vulvovaginitis compared to the subacute course of the disease, though no adequately high production of this cytokine is practically observed in both cases. The obtained data indicate the suppression of both the cell and humoral anti-inflammatory immunity. IL-6 is responsible for the specificity and the adequacy of immunological reactions. This fact is connected primarily with the presence of multidirectional pathological changes in the immunity system.

Highlights

According to the researchers of this problem, vulvovaginitis in not sexually active girls and adolescents is found in 63 to 83 % [1], more than 60% suffer from the recurrent form of the disease [2,3,4,5].According to studies, chronic vulvovaginitis is found in 48.1 % of girls during preventive medical examination, and in 29.8% of girls when they seek medical advice of a gynecologist [6]
The clinical pattern of subacute and acute nonspecific vulvovaginitis in the survey of 104 patients was represented by vulvitis and urethritis
The conducted study showed that increased production of anti-inflammatory INFγ cytokine is observed in girls and adolescents with acute nonspecific vulvovaginitis compared to the subacute course of the disease, though no adequately high production of this cytokine is practically observed in both cases

Summary

Introduction

According to the researchers of this problem, vulvovaginitis in not sexually active girls and adolescents is found in 63 to 83 % [1], more than 60% suffer from the recurrent form of the disease [2,3,4,5]. Chronic vulvovaginitis is found in 48.1 % of girls during preventive medical examination, and in 29.8% of girls when they seek medical advice of a gynecologist [6]. Transition of vulvovaginitis into chronic and recurrent state is connected with inadequately administered therapy, peculiarities of the infectant, decrease in immune reactivity of the body, including local immunity [2]. Studies of immunological aspects of inflammatory disease development mechanisms speak about the key role of imbalance in the system of subpopulations of Тh1/Тh2-lymphocytes mediated by cytokines [7,8,9]

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Conclusion