Abstract

The reduction of the chiral, racemic nitrone MiPNO provides a secondary hydroxylamine. Its O-acylation with O, O’-dibenzoyl- l-tartaric acid anhydride gives two diastereomers, that can be easily separated by selective dissolution in orthogonal solvents. The recovery of the enantiopure nitrone is then carried out in a single step. The process allows the straightforward isolation of ( R) and ( S)-MiPNO in 57% and 38% yield, respectively, from rac-MiPNO.

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