Abstract
Aim: A plaque may rupture with high risk of subsequent thrombus- mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. Focused ultrasound is one of the non- invasive methods to treat abnormal tissues. In pulsed- focused ultrasound with low duty cycle, which is used for thrombolysis, energy deposition rates are low enough that temperature rises are well below the threshold for thermal damage. The aim of this study was to generate a rabbit model of femoral artery atherothrombotic occlusion and the subsequent investigating the feasibility of combined laser and focused ultrasound thrombolytic therapy accompanied by thrombolytic agent (r-tPA) administration in this model.
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