Industrial importance seed kernel of Buchanania lanzan in contributing antioxidant, antidiabetic, and anticholinesterase activities

Abstract

This study aimed to evaluate the antioxidant, antidiabetic, and anticholinesterase activities of Buchanania lanzan Spreng seeds. The therapeutic significance of phytochemicals, minerals, and nutrition were quantified. Hydroalcohol-extract (HABL) possessed the highest phenol contents demonstrated superior inhibitory potential against oxidants in DPPH, CAP-e, and imparted total antioxidant capacity in ORAC test. HABL exhibited mixed-competitive inhibition against α-amylase and α-glucosidase. HABL exhibited mixed-competitive and competitive inhibition against acetyl-, and butyryl-cholinesterase. Seeds were a rich source of minerals, amino acids, protein, carbohydrates, volatile oil, and energy content. Reported Vit B3 and B6 in seeds were responsible for brain function, and neurotransmitter-synthesis. HPLC quantified phenols (gallic acid, chlorogenic acid, caffeic acid, rutin, and quercetin), and GC-MS identified (Catechol, 2-Hydroxy-5-methylbenzaldehyde, Hexadecanoic acid, methyl ester, n-Hexadecanoic acid, Hexadecanoic acid, ethyl ester, 8-Octadecenoic acid, methyl ester, 9,12-Octadecadienoic acid, ethyl ester, (E)-9-Octadecenoic acid ethyl ester, Heptadecanoic acid, 15- methyl-, ethyl ester, Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, 9-Octadecenoic acid (Z)-, 2-hydroxy-1-(hydroxymethyl)ethyl, and β-Sitosterol) in HABL exhibited antioxidant, antidiabetic, and anticholinesterase activities. B. lanzan seeds are given adequate attention for making medicines and dietary supplements in the pharmaceutical and nutraceutical industries.