Abstract
Transition metal-catalyzed cross-coupling reactions are among the most commonly employed reactions for the formation of new C–C and C–X bonds in synthetic chemistry. The increase in stereochemical complexity of pharmaceutically relevant compounds have resulted in an increase in demand for cross-coupling reactions that forge such bonds in an asymmetric manner. However, applications of asymmetric cross-coupling reactions on industrial scale remain challenging. In this Chapter, we will highlight examples of industrial applications of transition metal-catalyzed cross-coupling reactions that resulted in asymmetric bond formation through the use of either asymmetric catalysts, reagents or chromatography.
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