Abstract
Inductively coupled plasma mass spectrometry (ICP-MS) has been applied to the determination of platinum in blood, urine and tissue specimens taken from patients and experimental animals up to three months after the administration of cisplatin. Comparisons were made with graphite furnace atomic absorption spectrometry (GFAAS). Tissue specimens of from 0.1 to 300 g were prepared by nitric acid digestion and solution in dilute hydrochloric acid. As ICP-MS is highly specific and sensitive, giving detection limits below 0.1 µg l–1, matrix effects were small and compensated for by an indium internal standard. A detection limit of ca. 10 µg l–1 was obtained by GFAAS and matrix effects, particularly that of residual nitric acid, were much greater.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
