Abstract
ACTIDIONE (cyloheximide) inhibits protein synthesis in yeasts, certain protozoa and mammalian cell lines1–3. It is a toxic compound for some mammalian species, for example, rats; however, in these cases, hydrocortisone acts as an antidote against such poisoning4. We recently reported5 that actidione in rats stimulates the adrenal cortex by way of the anterior pituitary. The stress reaction protected rats against actidione while hypo-physectomy or adrenalectomy made them more sensitive to actidione poisoning5. Furthermore, mice (which are normally highly resistant to actidione poisoning4,5) became sensitive to actidione after adrenalectomy5.
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