Abstract
Background The effect of helminth infections on allergic diseases is still inconclusive. Several studies show that Treg cell induced by parasites down regulate the host Th2-mediated allergic response. However, some studies highlight the importance of alternative activated macrophages (AAM) in the pathogenesis of allergic diseases. This phenotype is also implicated in helminth survival. Our aim is to study the immunomodulatory effect of laminated layer (LL, accelullar layer of hydatic cyst) of the helminth Echinococcus granulosus. This infection remains a serious parasitic disease in Algeria.
Highlights
The effect of helminth infections on allergic diseases is still inconclusive
We have investigated the effect of LL extract (LLs) on IL-10 and IFN-g production by human mononuclear cells (PBMC) in vitro
The implication of TGF-b in the induction of activated macrophages (AAM) phenotype supports our finding of a concomitant activation of Treg and AAMs populations by LL
Summary
The effect of helminth infections on allergic diseases is still inconclusive. Several studies show that Treg cell induced by parasites down regulate the host Th2-mediated allergic response. Some studies highlight the importance of alternative activated macrophages (AAM) in the pathogenesis of allergic diseases. This phenotype is implicated in helminth survival. Our aim is to study the immunomodulatory effect of laminated layer (LL, accelullar layer of hydatic cyst) of the helminth Echinococcus granulosus. This infection remains a serious parasitic disease in Algeria
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