Abstract
Apoptosis is a genetically regulated cellular process, which plays an important role in conservation of homeostasis and protection from tumorigenesis. Apoptosis can be induced by various signals that activate the evolutionarily conserved core cell death apparatus, committing the cells to die. The commitment to cell death triggers a cascade of events that results in acquisition of morphological and biochemical features unique to apoptotic cells. These include alterations in the cytoskeleton leading to cell rounding, cell shrinkage and membrane blebbing; chromatin condensation; and DNA fragmentation. At the final stages, the cell fragments into apoptotic bodies that are engulfed by neighboring cells.
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