Abstract

Abstract The tolerogenic effect of the coccidioidal antigens was studied by injecting newborn guinea pigs, within 24 hr of birth, with killed hyphal cells of Coccidioides immitis in complete Freund's adjuvant (CFA). Such animals, when injected as adults with killed hyphal cells of C. immitis in CFA, did not respond with delayed hypersensitivity (DH) to coccidioidin as did other normal animals of the same age group, but they did exhibit DH to tuberculin. The tolerance to coccidioidin lasted for 3 to 6 months. Injection of newborns as late as 3 days after birth also induced tolerance which lasted for 30 to 60 days. Peritoneal macrophages from the coccidioidin-tolerant animals migrated normally in the presence of coccidioidin but were inhibited by tuberculin or PPD. The adoptive transfer of coccidioidin sensitivity to tolerant animals by intraperitoneal injection of peritoneal exudate cells from sensitized adult guinea pigs was possible. This transferred sensitivity was temporary and lasted for 3 to 5 days.

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