Abstract
Recent work on T-helper (Th) cell subset maturation has focused on defining the cellular source of early IL-4, which promotes precursor (naive) CD4 + Th cells to differentiate into Th type 2 (Th2) cells, and also on the roles of counter-regulatory cytokines, costimulatory signals, and antigen in the induction of Th2 responses. Results suggest that not all Th2 cells are equivalent in their ontogeny.
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