Abstract
While kidney alcohol dehydrogenase (ADH) was reported to be inducible by testosterone (Ohno et al. 1970a, b), testis ADH does not respond to this hormone. The inducibility of this enzyme by gonadotropins was investigated. Although follicle‐stimulating hormone (FSH) and human chorion gonadotropin (HCG) cause a similar increase of the weight of the testes of prepubertal rats, only HCG is active in stimulating testis ADH activity in these animals. Chronic injections of this hormone from the 17th day after birth onwards cause a sharp rise of ADH activity on day 24, surpassing the physiological increase which occurs in control animals during puberty (day 55). In 24‐day‐old rats, ADH activity can also be provoked by dibutyryl‐cAMP and by theophylline, applied separately or in combination. This effect can be enhanced by a brief pretreatment with HCG which does not cause an increase of ADH activity. It is suggested that HCG, after stimulating the development of Leydig cells, exerts its effect through the mediation of cAMP.
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