Induction of ‘sister-chromatid exchanges’ in human lymphocytes in vitro by extracts of airborne particulate matter: comparison of samples from a highly industrialized area followed up for several years

Abstract

In January 1985 an extended smog episode occurred in Central Europe. The Rhine-Ruhr area (Western Germany) was affected for 5 days with maximum concentrations of 0.8 mg/m3 SO2 and 0.6 mg/m3 TSP (24h averages). Health effects were investigated during the smog period and a control period before and after the smog. Daily mortality increased by 8%, hospital admissions (for respiratory and cardiovascular causes, RC) by 15%, outpatients (RC) by 12% and ambulance transports (RC) by 28%. Patients with chronic bronchitis from the Ruhr area cities showed more exacerbations during the episode, and in school children from the Netherlands lung function was reduced.In Augsburg (Southern Germany) the smog episode was less severe (maximum concentrations 0.2 mg/m3 SO2 and 0.1 mg/m3 TSP, 24 h averages). Here - by chance - the prospective MONICA study was ongoing. During the episode a significant increase of plasma viscosity, C-reactive protein and heart rate was observed in the participants.The highest ambient concentrations (maximum 24h average of 3.6 mg/m3 SO2) were measured in Erfurt (Eastern Germany). Surprisingly, no measurable increase of mortality occurred. This was explained by premature deaths during the period before the smog, were the concentrations had already been clearly above 1 mg/m3 SO2.An earlier episode took place in December 1962 in the Rhine-Ruhr area for 5 days with maximum concentrations of 5.0 mg/m3 SO2 and 2.4 mg/m3 TSP (24 h average). Daily mortality on average increased by 19%. In 1962 and 1985 the effects were stronger in cities with pollution mainly from traffic than in areas with pollution from industrial sources.In total, between 1962 and 1987 two major and several smaller smog episodes occurred in Central Europe. Patients with cardiovascular diseases were more severely affected than patients with respiratory diseases. Health effects were more strongly correlated with TSP than with SO2.