Abstract
An increase in oxidative stress plays a key role in neurotoxicity induction and cell death, which leads to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. Cyanidin-3-glucoside (C3G) is a common anthocyanin and shows antioxidant activity in neuronal cells. Silent information regulator 2-related protein 1 (Sirt1) regulates antioxidant and anti-inflammatory effects. However, the effects of C3G on Sirt1 in neuronal cells remain unclear. This study evaluated the effect of C3G on Sirt1 expression and activity in human neuroblastoma (SH-SY5Y) cells. In the study, C3G increased the expression of Sirt1 and Sirt1 activity in SH-SY5Y cells. Additionally, C3G increased the expression of nuclear factor erythroid 2-related factor 2, a vital transcription factor for regulating the expression of antioxidant genes, as well as antioxidant enzymes such as superoxide dismutase and catalase. Moreover, C3G protected SH-SY5Y cells from oxidative stress. These results suggest that C3G decreased oxidative stress-induced cell injury by increasing the expression of Sirt1 and other antioxidant factors. Therefore, C3G might merit further investigation for use in attenuating the progress of neurodegenerative diseases.
Highlights
The causes of Parkinson’s disease (PD) and Alzheimer’s disease (AD) are still unknown several environmental and genetic risk factors have been suggested [1]
An increase in oxidative stress plays a key role in neurotoxicity induction and cell death, which leads to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease
This study evaluated the effect of C3G on Silent information regulator 2-related protein 1 (Sirt1) expression and activity in human neuroblastoma (SH-SY5Y) cells
Summary
The causes of Parkinson’s disease (PD) and Alzheimer’s disease (AD) are still unknown several environmental and genetic risk factors have been suggested [1]. Some studies have reported that C3G protected neuronal cell death in human neuroblastoma cells from reactive oxygen species (ROS), apoptosis and inflammation [4] [5] [6] [7]. These reports indicate that C3G has an antioxidant capacity and may protect cells from oxidative stress involved in neurodegenerative diseases. This finding suggests that C3G has potential for treatment of neurodegenerative diseases like PD and AD. We examined the effect of C3G on Nrf expression in SH-SY5Y cells
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
