Abstract
4,5', 8-trimethylpsoralen (TMP) and 8-methoxypsoralen (MOP) plus long-wave UV light were found to be potent inducers of respiration-deficient mutants in yeast. TMP was found to be about 100 times as potent as MOP and gave a significant increase in the mutation rate at a concentration of 10 ‒7 ‒10 ‒8 M/Iiter. At concentrations of MOP and TMP that gave 100 % mutants the growth inhibition was rather small.
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