Abstract
The extent of induction of recA protein in Escherichia coli after treatment by cis-Pt(NH3)2Cl2, trans-Pt(NH3)2Cl2 and [Pt[(HNCH2CH2)2NH]Cl]Cl has been monitored via a 2 site immunoradiometric assay. The kinetics of induction are presented and, for an equal amount of platinum fixed on the DNA, the maximum relative amplification was found to be 22 : 5 : 2 respectively for the three platinum(II) compounds. A good correlation seems to exist between the extent of recA protein induction by these compounds and their previously reported mutagenic and antitumoral properties.
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