Abstract
The increased activity of rat ovarian 20α-hydroxysteroid dehydrogenase observed during proestrus and estrus results in an increased secretion of the biologically weaker or impotent steroid, 20α-hydroxypregn-4-en-3-one, from the gland. The decreased activity of this enzyme during pseudopregnancy allows the progestational potency of the ovarian secretion to rise commensurate with the need. The present study, performed on hypophysectomized prepubertal female rats, was designed to study gonadotrophic hormone action responsible for regulation of 200-hydroxysteroid dehydrogenase and glucose-6-P dehydrogenase activities. Both enzyme activities correlate positively with the process of interstitial cell and thecal cell luteinization achieved either by HCG administration or by simultaneous administration of FSH and LH. Levels of glucose6-P debydrogenase normally present in immature or adult rats are in excess of those required for estrogen biogenesis.
Published Version
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