Abstract
To search for novel cancer preventive agents, we assessed the quinone reductase (QR)-inducing activities of medicinal herb extracts in cultured murine hepatoma cells (hepa1c1c7 cells). Among 216 herb extracts tested in this study, 8 kinds of herbal extracts were found to induce QR activity in hepa1c1c7 cells by more than 2-fold when used at the concentration of 25 μg/mL. The methanol extracts of Aster koraiensis NK and Pulsatilla koreana Nakai induced QR by 252 and 223%, respectively, at the concentration of 25 μg/mL. Most of the herbal extracts with QR inducing-activity increased the enzyme activity in a typical dose-dependent manner. The QR activity in BPrc1 cells was induced more than 50% by the extracts of Pulsatilla koreana Nakai, Inula helenium, Physalis alkekengi var. francheti (Masters) Makino, Chrysanthemum zawadskii var. latilobum Kitamura, Artemisia keiskeana Miquel, Chrysanthemum boreale Makino. In conclusion, Pulsatilla koreana Nakai, Aster koraiensis N.K, and Chrysanthemum zawadskii var. latilobum Kitamura, which showed relatively high QR induction, merit further animal study to evaluate their potential as cancer preventive agents.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
