Abstract
AbstractWe verified the oncogenic effect ofpolyoma virus in gnotobiotic nude (nu/nu) mice compared to their gnotobiotic normal counterparts (nu/+). The nude mice were found to be much more sensitive to the oncogenic activity of the virus than were their heterozygote counterparts. This increased sensitivity is illustrated by the short latent period and by the high incidence of polyoma tumors in the nude mice inoculated with the virus several weeks after birth at a time when the nu/+ mice are completely resistant to polyoma oncogenesis.Moreover, the cytolytic lesions observed in the kidney and in the salivary glands were also much more conspicuous in the nude mice. The results are discussed in relation to the role of immune surveillance in oncogenesis.
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