Abstract
Ovulation induced by pituitary extracts in vitro was enhanced by addition of certain androgenic, progestational, and cortical steroids, but inhibited by estrogens. A number of nonestrogenic steroids also had potent ovulatory capacity in vitro in the absence of pituitary factors, progesterone being the most effective of those tested. A greater ovulatory efficiency was demonstrated for progesterone than for pituitary extract. It is proposed that the principal function of pituitary gonadotropins in ovulation may be to stimulate steroid production by ovarian tissue, and that steroids are the real agents responsible for ovulation.
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