Abstract
Exposing the myocardium to brief repeated episodes of ischemia and reperfusion has been shown to dramatically limit the size of infarct produced by a subsequent episode of sustained ischemia. We also found that the infarct-limiting effect was observed not only immediately after, but also 24 h after repetitive brief ischemia in dogs. The sublethal ischemia enhanced the myocardial activity of mitochondrial Mn-SOD associated with the increase in its content 24h after the treatment. Thus, sublethal ischemia-induced protection against myocardial injury could occur biphasically. Induction of Mn-SOD enzyme may contribute to the delayed phase of myocardial adaptation.
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