Induction of Menstruation in Women by Use of Ovarian Hormone.

Abstract

In cooperation with Claire Conklin, it was found that the basal metabolism of half the women students examined was low and was about 15% below the Aub-Dubois standard. Some of these were studied for prolonged periods but others for only one day so that, in the latter, variations were not considered. It is a significant fact that all of the cases of amenorrhea fell in the low basal group. The basal metabolism of the following women was at times 15% below normal but showed slight variations.In a previous communication we reported the use of injections of 2000 to 4000 mouse units of ovarian hormone in women and that it was excreted in the urine. Owing to this fact we supposed that repeated injections would be necessary in order to have any marked effects. Consequently, we tried the effects of daily injections into a woman, 19 years old, who had not menstruated for 5 months. One thousand mouse units were injected every day for 9 days. Then they were stopped. At the end of 3 weeks she had a menstruation which ...