Abstract
Industrial grade samples of bis(chloromethyl) ether and chloromethyl methyl ether were injected subcutaneously into newborn ICR Swiss mice at a maximum tolerated dose. Bis(chloromethyl) ether, dissolved in peanut oil, was injected at a dose of 12.5 μ1/kg, chloromethyl methyl ether at 125 μ1/kg, and the vehicle control mice received 0.05 ml of peanut oil only. The positive control animals received a high dose of 1500 mg/kg of urethan. The animals were sacrificed 6 months posttreatment, and the lung adenoma incidence was determined. Vehicle control animals had an incidence of 14% with a mean number per animal of 0.14. An incidence of 100% and mean of 17 was observed in the positive control animals receiving urethan. The animals receiving bis(chloromethyl) ether had an incidence of 45% with a mean of 0.64—each parameter significantly higher than the control values. The animals receiving chloromethyl methyl ether had an incidence of 17% with a mean of 0.21—high but not significantly different from the controls.
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