Abstract
The hypolipidemic agent clofibrate at a concentration of 0.5 mM in the culture medium maintained the cytochrome P-450 content of rat hepatocytes for up to 96 hr. This effect was associated with a marked induction of lauric acid hydroxylation whereas little effect was observed on the metabolism of three other cytochrome P-450 dependent mixed function oxidase substrates. The results suggest that clofibrate induces similar form(s) of cytochrome P-450 in cell culture to those observed in vivo and that primary cultures of rat hepatocytes may be useful for studies on both the peroxisomal and microsomal effects of hypolipidemic agents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
