Abstract
The induction of interleukin-1β (IL-1β) mRNA in the rat brain following subcutaneous injection of formalin into the hind paws was investigated by in situ hybridization. IL-1β mRNA was markedly induced in the hypothalamus after the injection of formalin into both hind paws. On the other hand, IL-1β mRNA was scarcely observed in the hypothalamus of saline-injected control rats. The type of cells expressing IL-1β mRNA was likely glia because their nuclei were densely stained by Cresyl violet and were relatively small. The present results suggest that IL-Iβ mRNA is induced in the glial cells of the hypothalamus by persistent pain which is caused by formalin injection.
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