Induction of Interleukin-13 Receptor Expression Via Nuclear Factor-Kappab Activation in Human Tonsillar B Cells

Abstract

RATIONALE: The ability of CD40 signaling to regulate B cell growth, survival, differentiation, and Ig class switching involves changes in gene expression. CD40 ligation activates the Rel/NF-κB transcription factors, which are major regulators of immune and inflammatory responses and potentially activates both type 1 (p105/p50) and type 2 (p100/p52) NF-κB activation pathways. Using primary B cells, we investigated the contribution of NFκb activation on CD40 mediated IL-13 receptor expression, using BAY11, an IkappaB-alpha phosphorylation inhibitor.