Abstract
Induction of influenza (H5N8) antibodies by modified vaccinia virus Ankara H5N1 vaccine.
Highlights
The development of representative candidate influenza vaccine viruses (CVV), coordinated by the World Health Organization (WHO), remains an essential component of the overall global strategy for pandemic preparedness
National authorities may consider the use of one or more of these CVVs for pilot lot vaccine production, clinical trials and other pandemic preparedness purposes based on their assessment of public health risk and need
A(H5) human infections have been reported to the WHO by Cambodia, China, Egypt and Indonesia, countries in which infections have been detected in birds (Table 1)
Summary
# denotes number of human cases with illness onset dates falling within reporting period †provisional, pending formal designation by the WHO/OIE/FAO A(H5N1) evolution working group. As compared to the CVVs produced from A/Egypt/N03072/2010 and A/Egypt/2321-NAMRU3/2007, the HA proteins of recent clade 2.2.1 viruses have accumulated a number of amino acid substitutions These viruses showed reduced reactivity to ferret antisera raised against the CVVs. Further virus characterization is underway. Clade 2.3.2.1c viruses were detected in birds and/or environmental samples in Cambodia, China, Indonesia, Lao People’s Democratic Republic and Viet Nam. The HA genes of the bird and. Antigenic analysis showed that many of these viruses reacted well with ferret antiserum raised against A/duck/Viet Nam/NCVD1584/2012 or A/barn swallow/Hong Kong/1161/2010 for which CVVs have been prepared. Antigenic information from viruses of this clade showed that they reacted poorly to ferret antisera raised against available CVVs and an A/Sichuan/26221/2014-like CVV is proposed.
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