Abstract
Epidemiological studies suggest that gut microbiota influences the prevalence of allergic diseases. Helicobacter pylori (Hp), a gastric commensal in half of the world’s population, is associated with protection against asthma. This protective effect has been attributed to Hp proteins exerting local and systemic immunomodulatory effects. We have assessed whether HpVac-R13, a recombinant protein derived from Hp, can generate immunological tolerance in vitro and in vivo and thereby modify the severity of allergic asthma in murine models.
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