Abstract
Pancreatic hepatocytes are induced in rats maintained on copper-deficient diet containing 0.6% d-penicillamine for 8–10 weeks, followed by copper repletion. These induced hepatocytes are morphologically and functionally very similar to parenchymal cells of the liver. Immunofluorescence stains demonstrated the presence of albumin and catalase in these cells. Strains for pancreatic enzymes and hormones were negative. As expected, the hypolipidemic compounds, ciprofibrate, induced peroxisome proliferation in these cells. These results indicate that a simple depletion and repletion of copper can trigger transdifferentiation in the pancreas of adult rats.
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