Abstract
1. Trout ( Salvelinus fontinalis) were fed PCB (Aroclor 1254) or 3-methylcholanthrene over and 18-day or a 25-day period, respectively, and the induction of hepatic MFO enzymes was studied. 2. Trout fed PCB to produce tissue concentrations of about 39 ppm showed a significant increase in the activity of ethoxycoumarin O-de-ethylase, and slight but non-significant increases in the activity of aniline hydroxylase, and in cytochrome P-450 and microsomal protein concentrations. 3. Trout fed 9 doses of 0.35 mg 3-methylcholanthrene showed significant increases in the activity of ethoxycoumarin O-de-ethylase, aniline hydroxylase, aldrin epoxidase and in concentrations of cytochrome P-450 and microsomal protein.
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