Induction of hepatic mixed-function oxidases by permethrin and cypermethrin in chicks fed vitamin A-deficient diet

Abstract

The effect of permethrin and cypermethrin on the induction of hepatic mixed-function oxidases was studied in chicks fed a vitamin A-deficient diet. Oral administration of permethrin at 10, 50, 100, and 200 mg/kg for 6 consecutive days induced microsomal protein, cytochrome P-450, and NADPH-cytochrome c reductase in dose-dependent manner. Treatment with cypermethrin at a dose of 200 mg/kg body weight induced NADPH-cytochrome c reductase and cytochrome b 5. However both insecticides had no effect on the glutathione S-transferase activity. Permethrin and cypermethrin appear to be weak inducers of hepatic microsomal mixed-function oxidases in chicks fed vitamin A-deficient diet.