Abstract
Induction of Heat Shock Proteins in the Therapy of Type 2 Diabetes and Metabolic Syndrome
Highlights
A remarkable 55% drop in albuminuria was observed in t2DM with a drop in serum creatinine
Low muscle intracellular Hsp precedes abnormal metabolic function by four years in non-human primates which is comparable to a decade in humans (Chichester et al, 2014)
Mitochondria biogenesis and mitochondrial function are improved by Hsp induction—augmenting reduction in adipose stores
Summary
A remarkable 55% drop in albuminuria was observed in t2DM with a drop in serum creatinine. Low intracellular Hsps in insulin sensitive tissues like skeletal muscle and liver may be the near sentinel event in the development of MET or t2DM. Low muscle intracellular Hsp precedes abnormal metabolic function by four years in non-human primates which is comparable to a decade in humans (Chichester et al, 2014). Normo-glycemic identical twins of siblings with impaired glucose tolerance have low muscle Hsp expression. Restoring the low Hsps via exercise or bioactive Hsp inducers normalizes the pathologic features of MS and t2DM.
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