Induction of funitatin A, a new polyketide from the Yellow River wetland-derived fungus Talaromyces funiculosus

Abstract

• A novel polyketide was isolated from fungus Talaromyces funiculosus by adding the HDAC inhibitor SAHA. • The structure of the new compound was determined by analysis of 1D and 2D NMR and HRESIMS spectra. • The new compound was the first microbial natural product bearing a rare dimeric cyclopaldic acid structure. • The new compound showed moderate antimicrobial activity against the Proteus species and Escherichia coli . A new, highly modified fatty acid ester, funitatin A ( 1 ), was isolated from the Yellow River wetland-derived fungus Talaromyces funiculosus HPU-Y01 cultivated with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). The structure of 1 was established by analysis of NMR and HRESIMS data. Compound 1 featured a rare dimeric cyclopaldic acid structure and showed promising antimicrobial activity against both Proteus species and Escherichia coli with MIC values of 3.13 μM.