Abstract
Female AKR (H-2k, Mlsa) mice were repeatedly injected with monoclonal anti-V beta 6 prior to and during syngeneic pregnancy. The offspring were born non-viable or died within 24 h. Continued injections into the mother resulted in abortions and conception eventually ceased altogether. Antisera from hyperimmunized mothers, when injected into the neonatal offspring of untreated AKR mothers, also had a lethal effect within 4 to 10 days after injection. Some mice survived for several weeks. All injected neonates developed a graft-versus-host disease (GVHD)-like syndrome characterized by runting, presence of skin lesions and weight loss. Antiserum injected in a diluted form caused similar but less severe symptoms. FACS (fluorescence-activated cell sorter) analysis of lymphocyte profiles of these mice revealed significant increases in the L3T4+ and Lyt-2+ T lymphocyte subsets; the number of V beta 6 T cells also increased. However Histopathological findings and mechanisms of the GVHD-like syndrome in these mice are discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
