Abstract
The induction and mechanism of fatty liver in the rat by the synthetic carcinogen 2-acetylaminofluorene (AAF) were investigated. The induction of this fatty liver was dose and time dependent, being gradually increased by the intake of a 0.05% AAF diet for 3 weeks. The AAF dosage was found to increase the activity of drug-metabolizing enzymes (p-nitroanisol demethylase and aniline hydroxylase) and to decrease the activity of pyruvate kinase and α-glycerophosphate dehydrogenase. The AAF dosage had no effect on the incorporation of [l-14C]acetate into the lipid fraction during in vitro incubation of liver slices. The supplement of adenine to the AAF diet had no effect on the accumulation of liver lipid. It is suggested from the result of treatment with Triton WR-1339 that a block in the secretion of triglyceride from the liver is a major cause of the induction of fatty liver by AAF.
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