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Abstract
Inorganic selenium compounds are shown to be inducers of hemoglobin synthesis in malignant murine erythroleukemia (MEL) cells. SeO 2 can induce hemoglobin synthesis at 1 20 the concentration of butyric acid and 1 5000 the concentration of dimethylsulfoxide (DMSO), two potent inducers of erythroid differentiation in MEL cells. SeO 2 and H 2SeO 3 showed an equivalent capacity to stimulate hemoglobin synthesis in three different MEL cell lines. The incorporation of 3H-glycine into hemoglobin was demonstrated in lysates of SeO 2-induced MEL cells.
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