Abstract
Aflatoxins B 1 , B 2 , G 1 and G 2 , highly toxic mycological metabolic products occurring as food contaminants, were capable in minute quantities of causing delayed hypersensitivity in guinea pigs. Structurally related compounds, sterigmatocystin (a mycotoxin), coumarin, 8-methoxypsoralen and furazolium chloride were also equally or more active in causing delayed hypersensitivity in guinea pigs. Animals which were strongly sensitized to aflatoxin B 1 showed cross-reactivity to other aflatoxins (B 2 , G 1 and G 2 ), sterigmatocystin, coumarins, 8-methoxypsoralen, furans and commerical perfumes. Less strongly immunized animals, on the other hand, showed differential cross-reactivity in that other aflatoxins produced frank erythema whereas closely related compounds were more moderate in action. None of these immunized animals showed any circulating antibodies.
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