Abstract
Background: We recently reported that hypoxia-inducible factor 1α (HIF-1α), HIF-2α and cyclooxygenase 2 naked DNA induced angiogenesis in a rat indirect bypass model. In this work, we investigated whether the collateral circulation induced by HIF-1α DNA affected the cerebral infarction.Methods: We utilized a rat encephalomyosynangiosis (EMS) model and inoculated HIF-1α DNA onto the brain surface. These treatments were performed before the cerebral infarction occurred. We thereafter performed middle cerebral artery occlusion on the fifth or tenth day after EMS.Results: A histological section treated with HIF-1α DNA for 10 days showed a well-developed collateral circulation (p<0.05) and a reduction in the infarction volume in comparison to the control DNA (p<0.01).Conclusion: These results suggest the feasibility of a novel approach for the treatment of cerebral ischemia via the development of therapeutic collateral circulation, in which neovascularization may be indirectly achieved using a transcriptional regulatory strategy.
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