Abstract
AbstractPregnant Holtzman rats were injected subcutaneously with anti‐inflammatory drugs from days 12–15 of gestation. Daily doses producing significant frequencies of cleft palate in the offspring ranged from 0.1–0.8 mg/day for triamcinolone, betamethasone, and dexamethasone. Cleft palate was not induced by methylprednisolone, prednisolone, and cortisone, even by daily doses ranging from 8–75 mg. Similar experiments were performed on A/J mice. The possible significance of these experiments in relation to testing potential teratogens and to the mechanism of palate closure is discussed.
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