Abstract
Chiral and achiral β-turn mimetic polymer conjugates were synthesized, and their chiroptical properties were investigated. Chiral helical poly(n-hexyl isocyanate)s (PHICs) with alkyne functional end groups (4.0–5.4 kDa) were synthesized via coordination polymerization using either a chiral or an achiral alkyne-functional organotitanium catalyst. The obtained helical polymers were coupled with a chiral β-turn mimetic structure using the copper-catalyzed azide/alkyne cycloaddition (CuAAC) reaction, in turn allowing to tune the distance between the PHIC-helix and the chiral center from 7 to 14 A. The successful linkage of the PHIC-helix to the β-turn mimetic was confirmed by size exclusion chromatography (SEC), high performance liquid chromatography (HPLC), 1H NMR spectroscopy, and MALDI-ToF mass spectrometry, proving the attachment of either one or two PHIC-helices to the central β-turn. Circular dichroism (CD) spectra confirmed chirality induction from the chiral β-turn mimetic structure to the polymer bac...
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