Abstract
Compared with traditional cytotoxic cancer therapy, therapy-induced cancer cell senescence represents a novel promising strategy because it has similar efficacy, but fewer side effects. In this chapter, we briefly review the basic concept of cellular senescence and therapy-induced senescence and discuss the signalling pathway of cellular senescence, especially, Ras and Twist signalling. Moreover, we focus on Caffeic Acid 3,4-Dihydroxy-Phenethyl Ester (CADPE), a natural compound from the medicinal plants Sarcandra Glabra (Sarcandra) and Teucrium pilosum (Decne), that suppresses human cancer cell growth and colony formation by the induction of cellular senescence, not by apoptosis or autophagy. Furthermore, we discussed the underlying mechanisms and show that CADPE suppressed the Twist1-related senescence signaling pathways. Together, our results demonstrate that CADPE induces human cancer cell senescence by suppressing Twist expression and that CADPE could be a novel effective agent in the treatment of tumors.
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