INDUCTION OF BRN-3B/POU4F2 IN CARDIAC MYOCYTES BY ANGIOTENSIN II CAN AFFECT FATE AND SURVIVAL DEPENDING ON CO-EXPRESSION WITH P53

Abstract

Early hypertrophic responses help the heart to maintain cardiac output and compensate for increased demand or workload. However, prolonged stresses trigger death of non-dividing cardiomyocytes and accompanying fibrosis, which underlies...