Induction of Bone Formation in Primates

Abstract

Introduction: The Discovery of Redundancy and the Bone Induction Prerogative of the Three Mammalian Transforming Growth Factor-ss Isoforms Ugo Ripamonti Induction of Bone Formation before Redundancy and the Discovery of the Induction of Bone Formation by the Mammalian Transforming Growth Factor-ss Isoforms Regenerative Medicine, the Induction of Bone Formation, Bone Tissue Engineering, and the Osteogenic Proteins of the Transforming Growth Factor-ss Supergene Family Ugo Ripamonti Regenerative Medicine and Bone: Formation by Autoinduction Induction of Bone Formation: Osteogenesis in Angiogenesis Homologous but Molecularly Different Pleiotropic Proteins of the TGF-ss Supergene Family Initiate Endochondral Bone Formation Rapid Induction of Bone Formation by the Transforming Growth Factor-ss3 Isoform Ugo Ripamonti Transforming Growth Factor-ss3 Isoform TGF-ss3 Isoform and the Induction of Bone Formation in Primates Coral-Derived Mascroporous Bioreactor as Delivery System for the Biological Activity of the Recombinant hTGF-ss3 Isoform hTGF-ss3 Master Gene and Gene Product: Transfiguration of Neoplastic Masses into Bone Induction of Bone Formation by the Mammalian Transforming Growth Factor-sss: Molecular and Morphological Insights Raquel Duarte, Kurt Lightfoot, and Ugo Ripamonti Introduction Role of TGF-ss in Differentiation of Osteoblasts Role of TGF-ss3 in Bone Formation: Lessons from the Nonhuman Primate Papio ursinus Perspectives Regeneration of Mandibular Defects in Nonhuman Primates by the Transforming Growth Factor-ss3 and Translational Research in Clinical Contexts Ugo Ripamonti and Carlo Ferretti Tissue Induction and Regeneration of Craniomandibulofacial Defects Rapid Induction of Bone Formation by the hTGF-ss3 Osteogenic Device in Mandibular Defects of the Chacma Baboon (P. ursinus) Synergistic Induction of Bone Formation by Relatively Low Doses of Transforming Growth Factor-ss1 and -ss3 in Binary Application with Recombinant Human Osteogenic Protein-1 Ugo Ripamonti Homologous but Molecularly Different Multiple Isoforms of the TGF-ss Supergene Family initiate the Induction of Bone Formation in Primate Species Tissue Morphogenesis and Synergistic Interaction by Interposed Homologous Recombinant Morphogens Synergistic Induction of Bone Formation Temporal Expression of Markers of Bone Differentiation by Induction: Mechanistic Insights into the Synergistic Induction of Bone Formation Synergistic Induction of Bone Formation in Full-Thickness Mandibular Defects of P. ursinus Induction of Periodontal Tissue Regeneration by Recombinant Human Transforming Growth Factor-ss3 with and without Myoblastic/Pericytic Stem Cells in Papio ursinus Jean-Claude Petit and Ugo Ripamonti Introduction Origins Periodontal Tissue Regeneration by the Osteogenic Proteins of the TGF-ss Supergene Family Periodontal Tissue Regeneration by Naturally Derived, Highly Purified and Recombinant Human Bone Morphogenetic Proteins Induction of Periodontal Tissue Regeneration by Recombinant Human TGF-ss3 in P. ursinus Challenges and Perspectives in Regenerative Medicine of the Periodontal Tissues by the hTGF-ss3 Isoform