Abstract
Discrete lesions in the rabbit brains were created at substantially lowered acoustic power levels when FUS exposures were combined with ultrasound contrast agent. In histology, the lesions exhibited numerous red blood cell extravasations and destruction of blood vessels, presumably caused by inertial cavitation. As early as at 4 h after sonication, the lesions lost many cells, and remaining cells exhibited both necrotic and apoptotic features. Overall, it appeared that apoptosis dominated; the average number of apoptotic cells/microscopic field was high: 32.3+/−13.2 compared to the number of necrotic cells: 5.1+/−3.4. In summary, it was found that sonication combined with an ultrasound contrast agent could produce lesions that are dominated by apoptosis. Apoptosis was presumably produced mostly via ischemia after cavitation‐induced damage and/or destruction of the vasculature.
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