Abstract
The apoptogenic activity of Litchi chinensis leaf extract (LCLE) was investigated against three human leuke- mic cell lines-U937, K562 and HL-60. LCLE inhibited cell growth and metabolic activity of the leukemic cells and showed characteristic features of apoptosis. Flow cytometric analysis showed appreciable number of cells in early and late apoptotic stages. While U937 and K562 cell populations were arrested in the G2-M phase, the HL-60 cell population was arrested in the G1 phase of cell cycle. LCLE induced apoptosis is mediated through mitochondrial intrinsic pathway in- volving the release of cytochrome c into the cytosol and activation of caspase-9 and caspase-3.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
