Abstract
The inhibitory effects of hybrid liposomes on the growth of human breast tumor (MDA-MB-453) cells in vitro were examined. The 50% inhibitory concentration of hybrid liposomes composed of 95 mol% dimyristoylphosphatidylcholine (DMPC) and 5 mol% polyoxyethylenedodecyl ether (C12(EO)23) was remarkably reduced compared with that of DMPC liposome and C12(EO)23 micelle. It was noteworthy that the induction of apoptosis by hybrid liposomes without antitumor drugs was obtained for human breast tumor cells.
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